Detroit Lions vs San Francisco 49ers Prediction Pick Point Spread Odds Line Week 2 09/16/2012

Sunday Night Football this week features the Detroit Lions trying to stop the San Francisco 49ers at Candlestick Park.

Kick-off is at 8:20 pm ET and the game will be broadcast nationally on NBC.

NFL Odds opened with the 49ers as a 7-point favorite and the line has dipped slightly to -6.5 at most sportsbooks. Moneyline odds have San Francisco as a -330 favorite and the Lions a +270 road underdog. The over/under total is at 47.

The 49ers have dominated the recent head-to-head series at 8-1 straight up and 5-2-2 against the number. The teams last met in a memorable matchup on Oct. 16 last season, when the 49ers beat the Lions 25-19, covering as a 5-point dog and ending Detroit’s unbeaten start to the season in Week 6.

That game is also known for a postgame confrontation between San Francisco coach Jim Harbaugh and Lions’ coach Jim Schwartz, when the two had to be separated following a less-than-friendly postgame handshake.

Detroit (1-0 SU, 0-1 ATS) beat the St. Louis Rams 27-23 last Sunday but failed to cover as an 8-point home favorite, while San Francisco (1-0 SU, 1-0 ATS) beat the Green Bay Packers 30-22 and cashed as a 6-point underdog.

NFL Handicappers trends show that the total has gone over in 5 of Detroit’s last 6 games, and San Francisco is 4-1 SU in its last 5 games.

The Detroit Lions vs San Francisco 49ers free NFL betting prediction is available right now to all callers to Lester’s courtesy line by dialing 1-800-293-0127.